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Journal Title: The Journal of Physiology
Authors and Corporations: Newman, P P, Reza, H
In: The Journal of Physiology, 287, 1979, 1, p. 405-426
ISSN: 0022-3751
1469-7793
DOI: 10.1113/jphysiol.1979.sp012667
Physical Description: 405-426
Media type: E-Article
Language: English
published:
author_facet Newman, P P
Reza, H
Newman, P P
Reza, H
author Newman, P P
Reza, H
spellingShingle Newman, P P
Reza, H
The Journal of Physiology
Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
author_sort newman, p p
spelling Newman, P P Reza, H 0022-3751 1469-7793 Wiley http://dx.doi.org/10.1113/jphysiol.1979.sp012667 <jats:p>1. Functional interrelationships between the hippocampus and the cerebellum have been investigated in the anaesthetized cat. Plots of the stimulating and recording sites as well as the latency range of the responses indicated the extent of ascending and descending lines of operation between these two structures. 2. Stimulation of the fastigial nucleus evoked the discharge of single hippocampal units on both sides of the brain. Early responses had a mean latency of 12 msec and late responses had a mean latency of 21 msec. Increasing the intensity of the stimulus had little effect on the patterns of discharge. 3. There was no topographical organization within the hippocampus. On the other hand, the activity evoked by a cutaneous stimulus was shown to be greatly depressed by a preceding cerebellar stimulus, particularly at intervals 30‐‐40 msec between the two stimuli. 4. Cerebellar responses evoked by stimulating the hippocampus were found mainly in lobule VI of the posterior lobe. Early and late responses were frequently recorded in the same trace, ipsilateral stimulation yielding the shortest latencies. Increasing the intensity of the stimulus increased the likelihood of there being a response and increased the number of spikes in each discharge. Hippocampal stimulation also had a profound influence on resting cerebellar discharges. 5. Symmetrical points in the two hippocampi were chosen for conditioning and testing sequences. The conditioning stimulus had a long‐lasting inhibitory effect on the test response followed by a slow recovery. 6. The location and extent of hippocampal influences on the cerebellum were determined by plotting the presence or absence of a response at each stimulated site. The results indicated the existence of bilateral descending projections containing fast and slow components in conformity with the known conduction properties of mossy fibre and climbing fibre inputs. 7. The physiological significance of interrelationship between the hippocampus and the cerebellum is discussed. It seems that there are many similarities as well as fundamental differences in the cerebellar control of movement under normal circumstances and in conditions of stress.</jats:p> Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat. The Journal of Physiology
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title Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_unstemmed Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_full Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_fullStr Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_full_unstemmed Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_short Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_sort functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
url http://dx.doi.org/10.1113/jphysiol.1979.sp012667
publishDate 1979
physical 405-426
description 1. Functional interrelationships between the hippocampus and the cerebellum have been investigated in the anaesthetized cat. Plots of the stimulating and recording sites as well as the latency range of the responses indicated the extent of ascending and descending lines of operation between these two structures. 2. Stimulation of the fastigial nucleus evoked the discharge of single hippocampal units on both sides of the brain. Early responses had a mean latency of 12 msec and late responses had a mean latency of 21 msec. Increasing the intensity of the stimulus had little effect on the patterns of discharge. 3. There was no topographical organization within the hippocampus. On the other hand, the activity evoked by a cutaneous stimulus was shown to be greatly depressed by a preceding cerebellar stimulus, particularly at intervals 30‐‐40 msec between the two stimuli. 4. Cerebellar responses evoked by stimulating the hippocampus were found mainly in lobule VI of the posterior lobe. Early and late responses were frequently recorded in the same trace, ipsilateral stimulation yielding the shortest latencies. Increasing the intensity of the stimulus increased the likelihood of there being a response and increased the number of spikes in each discharge. Hippocampal stimulation also had a profound influence on resting cerebellar discharges. 5. Symmetrical points in the two hippocampi were chosen for conditioning and testing sequences. The conditioning stimulus had a long‐lasting inhibitory effect on the test response followed by a slow recovery. 6. The location and extent of hippocampal influences on the cerebellum were determined by plotting the presence or absence of a response at each stimulated site. The results indicated the existence of bilateral descending projections containing fast and slow components in conformity with the known conduction properties of mossy fibre and climbing fibre inputs. 7. The physiological significance of interrelationship between the hippocampus and the cerebellum is discussed. It seems that there are many similarities as well as fundamental differences in the cerebellar control of movement under normal circumstances and in conditions of stress.
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author Newman, P P, Reza, H
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description 1. Functional interrelationships between the hippocampus and the cerebellum have been investigated in the anaesthetized cat. Plots of the stimulating and recording sites as well as the latency range of the responses indicated the extent of ascending and descending lines of operation between these two structures. 2. Stimulation of the fastigial nucleus evoked the discharge of single hippocampal units on both sides of the brain. Early responses had a mean latency of 12 msec and late responses had a mean latency of 21 msec. Increasing the intensity of the stimulus had little effect on the patterns of discharge. 3. There was no topographical organization within the hippocampus. On the other hand, the activity evoked by a cutaneous stimulus was shown to be greatly depressed by a preceding cerebellar stimulus, particularly at intervals 30‐‐40 msec between the two stimuli. 4. Cerebellar responses evoked by stimulating the hippocampus were found mainly in lobule VI of the posterior lobe. Early and late responses were frequently recorded in the same trace, ipsilateral stimulation yielding the shortest latencies. Increasing the intensity of the stimulus increased the likelihood of there being a response and increased the number of spikes in each discharge. Hippocampal stimulation also had a profound influence on resting cerebellar discharges. 5. Symmetrical points in the two hippocampi were chosen for conditioning and testing sequences. The conditioning stimulus had a long‐lasting inhibitory effect on the test response followed by a slow recovery. 6. The location and extent of hippocampal influences on the cerebellum were determined by plotting the presence or absence of a response at each stimulated site. The results indicated the existence of bilateral descending projections containing fast and slow components in conformity with the known conduction properties of mossy fibre and climbing fibre inputs. 7. The physiological significance of interrelationship between the hippocampus and the cerebellum is discussed. It seems that there are many similarities as well as fundamental differences in the cerebellar control of movement under normal circumstances and in conditions of stress.
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spelling Newman, P P Reza, H 0022-3751 1469-7793 Wiley http://dx.doi.org/10.1113/jphysiol.1979.sp012667 <jats:p>1. Functional interrelationships between the hippocampus and the cerebellum have been investigated in the anaesthetized cat. Plots of the stimulating and recording sites as well as the latency range of the responses indicated the extent of ascending and descending lines of operation between these two structures. 2. Stimulation of the fastigial nucleus evoked the discharge of single hippocampal units on both sides of the brain. Early responses had a mean latency of 12 msec and late responses had a mean latency of 21 msec. Increasing the intensity of the stimulus had little effect on the patterns of discharge. 3. There was no topographical organization within the hippocampus. On the other hand, the activity evoked by a cutaneous stimulus was shown to be greatly depressed by a preceding cerebellar stimulus, particularly at intervals 30‐‐40 msec between the two stimuli. 4. Cerebellar responses evoked by stimulating the hippocampus were found mainly in lobule VI of the posterior lobe. Early and late responses were frequently recorded in the same trace, ipsilateral stimulation yielding the shortest latencies. Increasing the intensity of the stimulus increased the likelihood of there being a response and increased the number of spikes in each discharge. Hippocampal stimulation also had a profound influence on resting cerebellar discharges. 5. Symmetrical points in the two hippocampi were chosen for conditioning and testing sequences. The conditioning stimulus had a long‐lasting inhibitory effect on the test response followed by a slow recovery. 6. The location and extent of hippocampal influences on the cerebellum were determined by plotting the presence or absence of a response at each stimulated site. The results indicated the existence of bilateral descending projections containing fast and slow components in conformity with the known conduction properties of mossy fibre and climbing fibre inputs. 7. The physiological significance of interrelationship between the hippocampus and the cerebellum is discussed. It seems that there are many similarities as well as fundamental differences in the cerebellar control of movement under normal circumstances and in conditions of stress.</jats:p> Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat. The Journal of Physiology
spellingShingle Newman, P P, Reza, H, The Journal of Physiology, Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_full Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_fullStr Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_full_unstemmed Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_short Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_sort functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
title_unstemmed Functional relationships between the hippocampus and the cerebellum: an electrophysiological study of the cat.
url http://dx.doi.org/10.1113/jphysiol.1979.sp012667